Summary
A stroke is a life-threatening condition that occurs when the blood supply to part of the brain is cut off by either a blood clot (85% of cases) or a burst blood vessel. Strokes affect some 15-17 million people a year, and they are a leading cause of death and disability. Urgent treatment is therefore essential to save the patient’s life and prevent further damage to the brain. Due to the potential for long-lasting consequences, stroke care involves a lengthy, complex pathway requiring coordination among multiple healthcare professionals. Unfortunately, many patients experience impaired care due to poor coordination between their healthcare providers.
The UMBRELLA project aims to revolutionise the way we manage strokes by implementing a comprehensive approach that addresses gaps along the whole stroke care pathway, from diagnosis and emergency treatment, right through to rehabilitation and the prevention of further strokes.
At the heart of UMBRELLA is a federated data platform dubbed the ‘U-platform’. The project will harmonise real world stroke data from participating clinical centres to a common data model. These datasets will then be used to locally create and validate artificial intelligence (AI) algorithms designed to advance stroke diagnosis, risk prediction, and decision-making at different points in the stroke care pathway.
The new AI algorithms will undergo further training and testing on other datasets via a federated learning framework. This approach ensures the AI models benefit from being trained on multiple datasets, but because the data is not shared or pooled, security and privacy are ensured.
The project also aims to create standardised stroke management protocols and procedures and implement them across the participating clinical centres. These protocols will include the use of digital technologies to collect and visualise data, engage patients, and facilitate decision making at all stages of stroke care.
Finally, the project will develop a regulatory roadmap to secure the approvals needed to implement the project outputs in patient care. They will also establish a sustainability plan to ensure the continued existence of resources like the U-Platform beyond the end of the project.
Participants
Show participants on mapUniversities, research organisations, public bodies, non-profit groups
- Eatris Eric, Amsterdam, Netherlands
- Erasmus Universitair Medisch Centrum Rotterdam, Rotterdam, Netherlands
- Fondazione Policlinico Universitario Agostino Gemelli Irccs, Roma, Italy
- Fundacio Eurecat, Cerdanyola Del Valles (Barcelona), Spain
- Fundacio Hospital Universitari Vall D'Hebron - Institut De Recerca, Barcelona, Spain
- Katholieke Universiteit Leuven, Leuven, Belgium
- Organisation Europeenne Pour La Recherche Nucleaire, Geneva 23, Switzerland
- Stichting Amsterdam Umc, Amsterdam, Netherlands
- Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany
- Universitat Basel, Basel, Switzerland
- Universitatsspital Basel, Basel, Switzerland
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
- Nico-Lab BV, Amsterdam, Netherlands
- Norahealth SL, Sant Cugat Del Valles, Spain
- Teamit Research SL, Barcelona, Spain
- Trianect BV, Utrecht, Netherlands
Patient organisations
- Stroke Alliance For Europe, Bruxelles / Brussel, Belgium
Third parties
- Fundacio Institut D'Investigacio Biomedica De Bellvitge, Hospitalet De Llobregat, Spain
- Instituto Pedro Nunes Associacao Para A Inovacao E Desenvolvimento Em Ciencia E Tecnologia, Coimbra, Portugal
- Neuravi Limited, Galway, Ireland
- Teamit Institute S L, Barcelona, Spain
Private companies
- Allm Emea GMBH, Dusseldorf, Germany
- Nacar Estudio SL, Barcelona, Spain
IHI industry partners
- Actelion Pharmaceuticals LTD, Allschwil, Switzerland
- Astrazeneca Farmaceutica Spain, S.A, Madrid, Spain
- Daiichi Sankyo Espana SA, Pozuelo de Alarcón, Spain
- Janssen Cilag SA, Madrid, Spain
- Janssen Research & Development, LLC, Raritan, United States
- Penumbra Europe GMBH, Berlin, Germany
- Philips France Commercial, Suresnes, France
- Philips Medical Systems Nederland BV, Best, Netherlands
- Siemens Healthcare Private Limited, Mumbai, India
- Siemens Healthcare SL, Getafe, Spain
- Siemens Healthcare Sro, Bratislava, Slovakia
- Siemens Healthineers AG, Forchheim, Germany
Participants | |
---|---|
Name | EU funding in € |
Allm Emea GMBH | 245 250 |
Eatris Eric | 253 000 |
Erasmus Universitair Medisch Centrum Rotterdam | 764 250 |
Fondazione Policlinico Universitario Agostino Gemelli Irccs | 647 250 |
Fundacio Eurecat | 561 050 |
Fundacio Hospital Universitari Vall D'Hebron - Institut De Recerca | 1 856 250 |
Katholieke Universiteit Leuven | 651 000 |
Nacar Estudio SL | 522 000 |
Nico-Lab BV | 309 000 |
Norahealth SL | 679 000 |
Organisation Europeenne Pour La Recherche Nucleaire | 817 250 |
Penumbra Europe GMBH | 337 500 |
Philips France Commercial | 127 606 |
Philips Medical Systems Nederland BV | 1 750 938 |
Siemens Healthineers AG | 2 252 085 |
Stichting Amsterdam Umc | 929 250 |
Stroke Alliance For Europe | 76 000 |
Teamit Research SL | 631 500 |
Trianect BV | 407 250 |
Universitaetsklinikum Hamburg-Eppendorf | 683 250 |
Third parties | |
Name | Funding in € |
Fundacio Institut D'Investigacio Biomedica De Bellvitge | 170 500 |
Instituto Pedro Nunes Associacao Para A Inovacao E Desenvolvimento Em Ciencia E Tecnologia | 67 750 |
Teamit Institute S L | 52 750 |
Total Cost | 14 791 679 |